
You shouldn't have to navigate the complexities of weight loss alone or through a revolving door of different providers. At MD Optimal Health & Aesthetics, you work exclusively with Melissa Donelson, a board-certified Nurse Practitioner who has spent 30 years mastering patient care and three years maintaining her own significant weight loss. Melissa keeps her practice small on purpose so that she can provide the high-touch, individualized support that large clinics simply cannot match. From virtual consultations in over 20 states to in-person care in Columbia, MD, she is here to help you solve the medical and behavioral puzzles that have held you back in the past. Together, we will create a manageable plan that fits your lifestyle and honors your body’s specific needs.

A medically supervised plan that combines GLP-1 medications, supplementation, nutrition, and individualized coaching

Comprehensive telehealth services available in over 25 states, including direct shipping of medications and supplements

One-on-one care managed exclusively by Melissa Donelson, a Certified Nurse Practitioner who has personally maintained a 100-pound weight loss

Sustainable, long-term weight loss achieved by individual triggers like hormones and establishing healthy, repeatable behaviors
"Weight loss is a very personal thing, and I really do understand this! I have struggled with being overweight most of my life, and I realize that not all plans and methods are a fit for everyone. Here at MD Optimal Health & Aesthetics, I want to focus on what plan or service will help you the most. We have a variety of options because not everyone is the same."
—Melissa Donelson, CRNP, Founder/Owner of MD Optimal Health & Aesthetics

Arizona | Colorado | Delaware | Florida | Idaho | Iowa | Kansas | Maryland | Montana | Nebraska | New Hampshire | New Mexico | New York | North Dakota | Oregon | South Dakota | Utah | Vermont | Virginia | Washington | West Virginia | Wyoming
Achieving weight loss with MD Optimal Health & Aesthetics is a seamless and personalized process designed to meet your unique goals. Here’s what you can expect:
Initial Consultation: Share your weight loss goals, medical history, and lifestyle. We’ll perform a thorough evaluation to determine the best treatment options for you.
Personalized Plan Creation: We’ll create a custom weight loss plan that may include GLP-1 agonists, Skinny Shots, or other medical treatments. We will also provide nutritional guidance and lifestyle recommendations to support your progress.
Ongoing Monitoring and Support: Regular follow-ups ensure your plan works effectively and allow us to adjust as needed. Our team is here to motivate and guide you every step of the way.
Achieve and Maintain Results: As you progress, we’ll provide tools and support to help you sustain your weight loss and live a healthy, fulfilling life.
Our weight loss solutions deliver benefits that transform your body and your life by combining proven medical treatments with lifestyle coaching.

Weight loss solutions at MD Optimal Health & Aesthetics are for individuals looking to achieve their ideal weight while improving their overall health and well-being. You may be a candidate for our customized weight loss programs if:

Success in our program is built on steady, sustainable progress. By balancing clinical tools like GLP-1 medications with targeted habit coaching, patients typically experience a reliable reduction in body fat while preserving lean muscle mass. You will likely notice an improvement in your metabolic health (such as better blood sugar levels and improved cholesterol) within the first few months of our partnership. My goal is to help you reach a maintenance phase where your new weight feels natural and easy to sustain. We track these milestones together during our virtual check-ins, ensuring that your results are as long-lasting as they are visible.
At MD Optimal Health & Aesthetics, we combine medical expertise and compassion to guide you to lasting weight loss. Founded by Melissa, a board-certified nurse practitioner with over 25 years of experience, our practice blends advanced medical training with a deep understanding of health and wellness. Melissa’s credentials include specialties in Internal Medicine, Critical Care, and Aesthetics, and she has personally coached over 350 clients to reach their weight loss goals. Her unique combination of clinical knowledge and personal experience makes her an exceptional guide on your journey to better health.
Melissa’s passion for weight loss coaching is rooted in her own success. After losing over 100 pounds and maintaining it, she understands the challenges and rewards of a sustainable approach. Melissa offers personalized guidance, including for clients with complex medical needs or those preparing for elective surgery. With cutting-edge strategies and a supportive, tailored approach, MD Optimal Health & Aesthetics empowers you to reach your goals safely and effectively.

Whether you prefer a private, one-on-one visit at our Columbia office or the convenience of a virtual consultation from your own home, I am ready to help you create your personal plan for success. Let’s work together to reclaim your energy and find a path to lasting vitality that truly fits your life.
Every body responds to treatment differently, but most patients begin to notice a difference in their energy levels and appetite within the first few weeks. Significant weight loss typically becomes visible within the first month of following your personalized "recipe" for health. Because we focus on sustainable behaviors alongside medications like GLP-1s, the goal is steady, consistent progress rather than a "quick fix" that is hard to maintain.
Yes, one of the most convenient aspects of our practice is our robust telehealth platform. I am licensed to provide virtual weight loss consultations and coaching in over 25 states. This means you can receive the same clinical expertise and one-on-one support from the comfort of your own home. We handle everything from the initial medical screening to shipping your medications and supplements directly to your door.
Plateaus are a normal part of the metabolic process, but they can be incredibly frustrating when you’re working hard. Because I manage your care personally, we can quickly pivot and adjust your plan if your progress stalls. Whether it’s tweaking your medication dosage, adjusting your vitamin therapy, or looking closer at your "recipe" for daily habits, I am by your side to help you navigate through the tough spots.
As a board-certified Nurse Practitioner with 30 years of clinical experience (including decades in acute care), your safety is my highest priority. During our initial consultation, I perform a comprehensive review of your medical history and any existing conditions. I am particularly adept at supporting clients with complex health needs, including those who have previously undergone weight loss surgery or are managing hormonal challenges.
While both are powerful tools in our weight loss toolkit, they serve different purposes. "Skinny Shots" are typically a blend of B-vitamins and amino acids (lipotropics) designed to boost your metabolism and energy levels. GLP-1 medications, such as Semaglutide, work on a hormonal level to regulate appetite and slow digestion. During your consultation, we will determine which of these—or which combination—is the right fit for your body’s unique needs.
While I offer structured meal replacement plans through Medi-Weightloss for those who prefer a clear roadmap, we can also work on building a plan around whole foods and sustainable eating habits. The goal is to find a way of eating that you actually enjoy and can maintain long after you’ve reached your target weight.
We currently serve patients in the following states: